Catalog Number - 40008-PG5

The 40008‑PG5 Cogent Bidentate C8 Guard Column Cartridges are replacement cartridges designed to protect standard‑flow analytical HPLC columns from particulates, sample contamination, and strongly retained compounds, helping maintain system performance and extend column lifetime.

Each cartridge is:

• 4.0 mm ID × 10 mm length

• Packed with 4 µm, 100 Å TYPE‑C™ silica hydride Bidentate C8 phase

• Built in stainless steel housings with SS frits

All cartridges are individually packaged in protective Delrin™ cases, preventing contamination, drying, or physical damage before use.

⚠️ Requires guard column holder (sold separately)

Designed for Standard Analytical Column IDs

These cartridges are optimized for:

• 3.0 mm ID solvent‑saving columns

• 4.0 mm ID analytical columns

• 4.6 mm ID standard HPLC columns

Ideal for conventional HPLC systems, these cartridges ensure:

• Minimal impact on peak shape

• Maintained chromatographic efficiency

• Consistent method reproducibility

Why Use Replacement Guard Cartridges

Analytical columns are routinely exposed to:

• Particulates from samples and solvents

• Strongly retained or irreversible contaminants

• Matrix buildup from complex samples

• Chemical fouling and degradation

The 40008‑PG5 cartridges act as a sacrificial protection layer, helping to:

• Extend analytical column lifetime significantly

• Prevent irreversible column damage

• Maintain consistent chromatographic performance

• Reduce cost per analysis

Cartridges can be replaced quickly without disturbing the analytical column setup.

Bidentate C8 Guard Phase Advantages

Using the same phase as your analytical column ensures:

• Matched selectivity and retention behavior

• No change in chromatographic performance

• Seamless analyte transfer to the main column

Compared to C18 phases, Bidentate C8:

• Reduces excessive hydrophobic retention

• Improves recovery of amine-containing compounds

• Provides alternative selectivity for complex mixtures

• Supports faster equilibration times

Cogent TYPE‑C™ Technology Benefits

Silica Hydride Surface

• Reduced silanol interactions

• Improved peak shape for basic analytes

• Lower secondary interactions

Faster Equilibration

• Reduced run‑to‑run cycle times

• Increased analytical throughput

Durability

• Resistant to hydrolysis

• Long cartridge lifetime

• Stable performance under routine analytical conditions

Typical Applications

• Standard analytical HPLC workflows

• Pharmaceutical and QC testing

• Method development and routine analysis

• Complex sample matrices

• Applications using 3.0–4.6 mm ID columns